Tomb raider the last revelation on demul causes random chipmunk noises on voices, and general cutting out of audio. It also cannot save/load memory cards without hex editing the memory card
I noticed those too, until I changed the Demul sound configuration to disable DSP. I did a side-by-side comparison of NullDC and Demul on the same game (Shenmue) by muting one and then the other, and apart from volume levels, it was exactly the same.